Azendus™ Mood 400MG
Azendus™ Mood 400MG
Azendus™ Mood 400MG
  • Azendus™ Mood 400MG
  • Azendus™ Mood 400MG
  • Azendus™ Mood 400MG

Azendus™ Mood 400MG

Actual Name: Samesyl™ Butanedisulfonate
Form: Plant Based Enteric Coated Tablets
Product Availability: In Stock
Free Shipping Offer
$43.95 (Buy 3+)


Daily Recommended Dosage: Take 1-2 tablets per day, or as recommended by your certified health care provider. If your SAMe levels are deficient and to determine the proper dose that works for you, use an initial loading phase of 1200mg-1600mg (3-5 tablets) daily (maximum 1600mg/day) for up to two weeks then reduce daily intake to 400mg-800mg (1-2 tablets), until benefits are achieved. Azendus™ supports the replenishment of S-Adenosylmethionine levels and balances the interactions of your immune system, maintains cell membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine. S-Adenosylmethionine (SAMe) is a naturally occurring compound that is found in almost every tissue and fluid in the body.*

SAMe supports brain function and brain cell neuronal health by boosting levels of neuroprotective compounds L-Glutathione (GSH) & Superoxide Dismutase (SOD). SAMe's ability to both sustain emotional well-being and combat brain aging has been established by leading universities and medical organizations.

SAMe significantly increases the liver’s glutathione level. This is critical because glutathione is the chief antioxidant produced in the liver, also known as the “super antioxidant”. Age, stress, free radicals and environmental conditions can dramatically impact the liver’s health and accelerate the aging process. Azendus™ SAMe is converted into glutathione, thus having the therapeutic benefits for the liver to combat oxidative stress, cellular damage, free radical activity and DNA breakdown, allowing the body to detoxify. This is one reason why SAMe supplement may be helpful in replenishing the necessary supply your body needs to help maintain or restore healthy liver functions and detoxification.*

Azendus™ is formulated with Pharmaceutical Grade S-Adendosylmethionine Butanedisulfonate. SAM-e is made naturally by microbiological fermentation and then specially processed in a ultra-low moisture and temperature controlled clean-room to preserve 68-80% (S,S) SAMe, the highest active level available. Azendus™ plant based enteric coating is formulated to pH release in the small intestine for maximum bioavailability and absorption.*

Azendus™ is the only SAMe with a Natural Plant based coating. No plastic co-polymer coating material- only pure Pharmaceutical Grade SAMe and Gentle Plant derived enteric coating materials.*

Azendus™ is packaged in individual tamper proof foil blister-packed to maximize stability and safety. DO NOT use if outer seal of blister pack is broken.

Keep out of reach of children. Store in a cool, dry place. Does not have to be refrigerated.


Tamper resistance blister card. Azendus™ SAMe tablets should be kept in the blister card until you take them. Do not take tablet, if the blister card compartment for that tablet has been tampered or compromised.

WARNING: Please consult your certified and knowledgeable healthcare practitioner before taking any dietary supplement. Keep out of reach of children. Do not use if blister card is compromised.

Customer Reviews

Review Summary
13 Reviews
100% (13)
0% (0)
0% (0)
0% (0)
0% (0)
100% Recommend this product (13 of 13 responses)
By Mistie
Best quality
August 4, 2022
I use Sam-e for all of it's perks, mood, liver, and joints and love it! It's the only supplement I don't forget to take. I take 1200mg daily... I should probably take more but it's a bit pricey as is. This brand in particular is my favorite, along with this company! Fits in well with my clean lifestyle and I don't have to be worried about odd fillers etc.! The brand is clean and doesn't hurt my stomach- which I am sensitive to big time. Other more "natural" brands didn't seem effective but this one does! Thank you extreme V and Azendus!
Effective at high enough doses Clean Easy on Tum Price
By Jo-Anne
Brooksville, FL
Very pleased with results
July 26, 2021
A couple of years ago I fell into a funk and was prescribed antidepressants. The first made my heart race and I never felt quite right. The second didn't seem to do much after a short while so I stopped it. After looking at various options, I decided to try SAM-e. First tried a different brand, and while I found it effective at improving my overall mood, it really bothered my stomach. After looking about online and asking questions on forums, I saw recommendations for Azendus and decided to give it a try. I have been really pleased. It doesn't upset my stomach and I find I do well on just 400 mg each morning. I've been taking it for about 6 months now and plan to continue taking it. I notice a difference on any days I forget to take it, as does my family, so it is still necessary.
No stomach upset like other brands Effective at relatively low doses A little pricier
By yourfriendcaspian
New England
The Only SAMe To Be Recommended By Name!
June 6, 2021
I've had SAMe recommended to me by several medical professionals and every one of them specifically recommended Azendus. I usually don't go in on name brands because generally the generic brands are the exact same thing, but when all the professionals suggest the same name brand I make an exception. Azendus SAMe is well worth the extra cost.
The only SAMe to be recommended to me by name from several medical professionals!
By jennifer
Best Sam-e
June 3, 2021
I have tried many brands of Sam-e, and this is the only one that does not upset my stomach and that actually works for my knee pain. The others make me feel edgy and wired, but this has zero side effects. Without this, I have constant knee pain even after surgery. But if I am consistent with taking this daily, I feel good and can jog, hike and stay active. Plus it helps my moods. Love it.
By Vanessa
February 11, 2021
this supplement has been used as an antidepressant in the treatment of OCD, with excellent results and no side effects. Thank you for offering this alternative.
ease of purchase, individually packaged tablets, no gastric damage,
Columbus, Ohio
Great Results
November 21, 2020
I have been on this for a few months. It has changed my life without any side effects. Before taking these, my mild depression was debilitating; and now I just have a bad day without spiraling. It may not work for those with severe depression but if it’s a mild form, give it a few months and it might be just what you need without the side effects of anti-depressants.
By Violet
Better than SSRIs
August 23, 2020
I've had depression for 30+ years and 8 years ago I discovered SAM-e after reading about it in a book by Dr. Andrew Weil. It has been a godsend. It has none of the side effects of SSRIs and it has the benefit of reducing joint pain. I take 400 mg daily and is an essential part of my mental health plan. I buy this brand because it's the best potency for the price.

Start with 200mg a day and see how you feel. You can go up to 1200mg without side effects but 400mg is plenty for me.

JUST WATCH OUT: This works great for my biology but I recommended it to someone else and it triggered a manic episode for them. If you take this and start feeling bizarrely euphoric and overconfident or have other symptoms of mania discontinue it IMMEDIATELY. The goal is to just feel regular happy and self-assured, not a danger to yourself or others.
By Bonnie
Denver, CO
I have been on it for a far so good
April 12, 2020
I was on Lexapro 10mg and felt good on it, but did not want to be on a anti-depressant for the rest of my life so weaned off of it and started the SAM-E...I feel great on it but only on 400mg, so don't know if I want to go to the 800 or not per day...Have a question though anyone know is it ok to have alchohol while on the SAM-E I know you could not on the Lexapro. I cannot find info on the alchohol interaction anywhere...I am not a big drinker but would love to have a glass of wine now and then...thanks
By Jane
If prescription antidepressants cause too many side effects, try this
February 8, 2020
This is a good product, I’ve been taking it for around a year now and it works as well as any prescription I’ve tried but without the side effects. I researched them as well and the Azendus brand was highly recommended for purity and consistency. I used to order these from Amazon where ExtremeV was the supplier, but when I discovered ExtremeV gives you points for a substantial discount on future purchases, I started ordering directly from them. I’ve never had a problem with any of my orders and they are delivered promptly. Completely satisfied customer here!
By Jamie
Limbic Relief
January 5, 2020
This is the best SAMe my husband has tried to help with limbic ADD.
By Lina
Feeling Positive and giving me my energy!
January 5, 2020
This product is making a huge difference in my life. I am feeling positive and my energy is returning. Thank you, thank you!
By Drew
San Francisco, CA
Authentic Source of SAM-e
December 6, 2019
If you do your research you will find this is the best form of SAM-e. Excellent product! Works great! You need to take it for at least a month for your body to adjust and for it to work.
By Kyle
Colorado Springs, CO
Very Trustworthy
October 24, 2018
This company is great and I trust their product. SAMe is really great for those who need it. If you have health issues make sure to get all the tests that are recommended and then start working on your health. Do not guess and you will save a lot of time.