Azendus™ Joint 400MG
Azendus™ Joint 400MG
Azendus™ Joint 400MG
Azendus™ Joint 400MG
Azendus™ Joint 400MG
  • Azendus™ Joint 400MG
  • Azendus™ Joint 400MG
  • Azendus™ Joint 400MG
  • Azendus™ Joint 400MG
  • Azendus™ Joint 400MG

Azendus™ Joint 400MG

Actual Name: Samesyl™ Butanedisulfonate
Form: Plant Based Enteric Coated Tablets
Product Availability: In Stock
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$43.95 (Buy 3+)


Daily Recommended Dosage: Take 1-2 tablets per day, or as recommended by your certified health care provider. If your SAMe levels are deficient and to determine the proper dose that works for you, use an initial loading phase of 1200mg-1600mg (3-5 tablets) daily (maximum 1600mg/day) for up to two weeks then reduce daily intake to 400mg-800mg (1-2 tablets), until benefits are achieved. Azendus™ supports the replenishment of S-Adenosylmethionine levels and balances the interactions of your immune system, maintains cell membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine. S-Adenosylmethionine (SAMe) is a naturally occurring compound that is found in almost every tissue and fluid in the body.*

SAMe reduces sensitivity and stiffness in aging individuals and helps support healthy joints. SAMe can stimulate the reproduction of joint connective tissue and improve cartilage function-the key to reversing joint sensitivity and discomfort.

SAMe significantly increases the liver’s glutathione level. This is critical because glutathione is the chief antioxidant produced in the liver, also known as the “super antioxidant”. Age, stress, free radicals and environmental conditions can dramatically impact the liver’s health and accelerate the aging process. Azendus™ SAMe is converted into glutathione, thus having the therapeutic benefits for the liver to combat oxidative stress, cellular damage, free radical activity and DNA breakdown, allowing the body to detoxify. This is one reason why SAMe supplement may be helpful in replenishing the necessary supply your body needs to help maintain or restore healthy liver functions and detoxification.*

Azendus™ is formulated with Pharmaceutical Grade S-Adendosylmethionine Butanedisulfonate. SAM-e is made naturally by microbiological fermentation and then specially processed in a ultra-low moisture and temperature controlled clean-room to preserve 68-80% (S,S) SAMe, the highest active level available. Azendus™ plant based enteric coating is formulated to pH release in the small intestine for maximum bioavailability and absorption.*

Azendus™ is the only SAMe with a Natural Plant based coating. No plastic co-polymer coating material- only pure Pharmaceutical Grade SAMe and Gentle Plant derived enteric coating materials.*

Azendus™ is packaged in individual tamper proof foil blister-packed to maximize stability and safety. DO NOT use if outer seal of blister pack is broken.

Keep out of reach of children. Store in a cool, dry place. Does not have to be refrigerated.


Tamper resistance blister card. Azendus™ SAMe tablets should be kept in the blister card until you take them. Do not take tablet, if the blister card compartment for that tablet has been tampered or compromised.

WARNING: Please consult your certified and knowledgeable healthcare practitioner before taking any dietary supplement. Keep out of reach of children. Do not use if blister card is compromised.

Customer Reviews

Review Summary
3 Reviews
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100% Recommend this product (3 of 3 responses)
By Patricia G.
Kingston, New York
Integrative Psychiatrist Gives 5 Stars to Azendus for Depression and Brain Health
October 29, 2017
As an Integrative Psychiatrist, I have used and prescribed many SAMe products over the past 17 years. Other brands have changed their formulas to cheaper and less potent SAMe. I am delighted to find Azendus contains the original pharmaceutical grade SAMe in a tablet that retains potency.
Compared to other brands, Azendus provides excellent antidepressant activity, increases energy, and enhances cognitive function.
Patricia Gerbarg, MD. Co-author of "How to Use Herbs, Nutrients and Yoga in Mental Health Care" and "Non-Drug Treatments for ADHD;" co-editor of "Complementary and Integrative Treatments in Psychiatric Practice" (American Psychiatric Association Publishing, 2017)
Excellent quality Effective antidepressant Good for fatigue When combined with other nutrients, improves cognitive function Fair price None
By Shanna
Lakemoor, IL
Helps with Fibromyalgia
May 19, 2019
This has helped me be able to move around better and feel more positive. Side note: all three types of SAMe are the same and come in 200 or 400mg. If you are starting out, start small for a couple of weeks. Typically, I take one to four tablets of the 400 mg a day, but notice that now I need only one or two a day which I take as a sign that it's working. It's a must-have for fibromyalgia or depression especially the depression of having to deal with chronic pain.
Start off with one a day for a week or two. If you take more than your body needs, you may get nauseated or too easily angered as least that's what I've noticed.
By Michael
Excellent results
March 8, 2019
I was recommended this product by my father, and in one weeks time, the difference was unbelievable ! My knees don't ache like before I started using this product. Thank you for helping my aching knees.